Hi,
problem solved. At the end of the day one route was an issue. I misinterpreted debug.log - it was the same route again and again.
As I create RealDrive scenarios I added into the Scenario folder a subfolder
RailWorks\Content\Routes\b2b159c4-d721-48a4-9af2-1be86ecc71d5\Scenarios\Vlara VnM UH\Vyber\8947a6a1-ea20-4f4f-aa69-22acacc59399 - 15AI BojSlvUhBrKun - 15xAI plus mezicile\
which is empty. TS2022 didn't care about that but RWE 2 did and crashed. After packing it into .zip file, the problem is solved and RWE2 works perfectly.
Thanks a lot for such a great SW!